The aim of investigation is to describe the clinical case of a patient with Wiskott-Aldrich Syndrome. Materials and methods. We present a clinical case of a boy born in 2007 with a clinical picture of primary immunodeficiency, manifested in the form of Wiskott-Aldrich Syndrome. The child is under the supervision of a hematologist and immunologist at the Center for Pediatric Hematology, Oncology and Clinical Immunology. Results and discussion. The boy had a wide range of clinical and laboratory symptoms, such as a serious condition of the child, severe intoxication, hepatosplenomegaly, petechial rashes on the skin of the body, hemorrhagic syndrome, anemia of unknown origin in the blood, leukocytosis, accelerated ESR, thrombocytopenia. Taking into account all the above indicators and data, Primary Immunodeficiency, Wiskott-Aldrich Syndrome diagnosis was established. Conclusion. Based on this clinical case, one can be convinced that the clinical picture, including the characteristic triad of symptoms of this disease, is quite specific. Consequently, it helps doctors in differential diagnosis with other diseases.

In Children, early immunity to X pylori infection may serve as a model for pathological response and learning. In the conditions of the Republic of Uzbekistan, such studies have not been carried out, however, weight gain, a tendency to rejuvenation and a high incidence of complications dictate the need to study this issue. Patients and methods. The aim of the study was to include children with gastroduodenal pathology associated and not associated with CP from the entire cohort of examined children. Materials and methods of the study: According to the tasks set, out of the entire cohort of examined children, children with HP associated and non-associated gastroduodenal pathology were included in the study. We conducted a study of immune response mediators using IL-1ß and TNFa as an example in 165 sick children and, for comparison, in 50 practically healthy children of the same age who made up the control group. Based on the above, groups of children with H.pilori "+" and H.pilori "-" pathology of the gastroduodenal zone were divided into 2 subgroups depending on age. Results: The levels of IL-1B in the control group of children aged 7-14 years were 21.6±0.86 pg/ml compared with 24.2±0.72 pg/ml in children aged 15-18 years. In children aged 15-18 years, 27.4±0.76 pg/ml.

Purpose: to develop prognostic criteria for the outcomes of ART programs in women with infertility in PCOS based on molecular genetic predictors of folliculogenesis disorders. Material and research methods. To solve the tasks set in the work, 125 women were examined: group first - 45 women with primary PCOS and infertility; group second - 46 women with infertility and PCOS in preparation for ART; group third 26 conditionally healthy women. Based on the foregoing, we presented the data of our own studies on the assessment of the state, the genes of steroid hormones (CYP17A1-rs743572, CYP19A1-rs247015) based on the analysis of laboratory data. Results and its discussion. Regarding the influence of the polymorphism of the CY19A1 rs2470152 gene on the development of PCOS, mutant alleles were found to be significantly higher in patients than in the control group. When we divided the main group into MC(+) and MC(-) in terms of CYP19A1 and compared with the control group, we found that the homozygous mutant genotype was found to be greater in the MC(+) and MC(-) group compared to the control group. With this, we can conclude that the homozygous mutational form of the CYP19A1 gene plays a convincing inducible role in PCOS and our result was significant (chi2 - 5.74; p<0.02 in the main group; chi2=5.2; p=0.02 in patients with metabolic syndrome and chi2=3.9; p<0.05 in patients without metabolic syndrome). However, the study did not reveal an induced effect on the heterozygous genotype in the development of PCOS (chi2<3.85; p>0.05). At the same time, the wild-type homozygous variant played a protective role in terms of the appearance of PCOS in the main group, as well as in the MC (+) and MC (-) groups (OR=0.5). When it comes to the Hardy Weinberg equation, we found no significant difference between the expected and observed results in the main group. Estimates of polymorphism prediction efficiency, as already mentioned, showed only 0.6, which means that the prediction efficiency was not reliable in terms of mutant allele and genotype. In conclusion, from the study of CY17A1 polymorphism in patients with PCOS, it can be said that the GG mutant genotype was statistically significantly more common in patients compared to the control group. When dividing PCOS patients, they were divided into groups and compared with the control group, MS+ PCOS patients had a lower level of the mutant form (GG) genotype compared to the control group, but in MS-PCOS patients compared to the control group, the mutant gene was determined more.

The aim of the study was to study the clinical, biochemical and immunological features of chronic bronchitis in children. Under our supervision there were 40 children with chronic bronchitis aged from 3 to 15 years. Our results show that in chronic bronchitis, clinical and functional studies are essential in the timely diagnosis of the disease.In chronic bronchitis, there is a significant activity of LPO-AOS processes in the lymphocyte membrane, which is expressed by an increase in the level of MDA and DC, which were higher in the group of patients aged 7-15 years. The study of the immune status revealed profound changes in the T-cell link of immunity in the form of a significant decrease in the number and functional activity of neutrophils.

The aim of the study was to study the clinical, biochemical and immunological features of chronic bronchitis in children. Under our supervision there were 40 children with chronic bronchitis aged from 3 to 15 years. Our results show that in chronic bronchitis, clinical and functional studies are essential in the timely diagnosis of the disease.In chronic bronchitis, there is a significant activity of LPO-AOS processes in the lymphocyte membrane, which is expressed by an increase in the level of MDA and DC, which were higher in the group of patients aged 7-15 years. The study of the immune status revealed profound changes in the T-cell link of immunity in the form of a significant decrease in the number and functional activity of neutrophils.

The review presents the features of the clinical course of early neonatal adaptation of premature infants depending on the method of delivery of pregnant women with severe preeclampsia. A more favorable course of neonatal adaptation of premature babies from mothers with preeclampsia extracted by caesarean section has been established. A decrease in the incidence of RDS syndrome, morbidity and mortality in premature infants extracted surgically with preeclampsia has been proven.